top of page

Senior Manager - TPRM

Boston, MA (Hybrid)

Job Type

Full Time

Organization

Vertex Pharmaceuticals

Application Deadline

January 22, 2026

About the Role


General Summary

The Senior Manager, Third-Party Risk Management (TPRM) will serve as the Subject Matter Expert (SME) for the operational processes of the enterprise-wide TPRM program. Reporting to the Senior Director of Strategic Sourcing Enterprise Third-Party Risk Management, this role will focus on managing day-to-day TPRM operations, ensuring seamless stakeholder engagement, and providing excellent user support.

The Senior Manager will act as a liaison between vendors and business owners, triaging questions, facilitating communication, and tracking issues to resolution. The role also includes supporting the use and maintenance of TPRM tools (e.g., ProcessUnity, Archer, RiskConnect, or similar platforms) and driving the resolution of findings and issues identified during risk assessments.

The ideal candidate will have a strong background in operational process management, stakeholder engagement, and third-party risk tools, with a collaborative and service-oriented approach. Experience in biopharma, biotech, or a related field is preferred but not mandatory.

Key Duties & Responsibilities

Operational Support & Subject Matter Expertise

Serve as the SME for TPRM operational processes, providing guidance and support to stakeholders across the organization.
Manage the day-to-day operations of the TPRM program, ensuring efficient execution of processes and adherence to timelines.
Support the use and maintenance of TPRM tools (e.g., ProcessUnity, Archer, RiskConnect), ensuring data accuracy and system optimization.
Track and drive the resolution of findings and issues identified during third-party risk assessments.
Support root cause analysis and corrective actions for third-party risk incidents to prevent recurrence.
Partner with owners of Vertex's risk lanes (Operational, Financial, Regulatory, Structural) to facilitate the execution and tracking of TPRM risk assessments.
Develop and maintain risk metrics, dashboards, and reports to provide visibility into TPRM activities and outcomes.

Stakeholder Engagement & User Support

Provide excellent user support to business owners, risk subject matter experts (SMEs), and other stakeholders involved in the TPRM process.
Act as a liaison between vendors and business owners, triaging questions, facilitating communication, and ensuring timely resolution of issues.
Collaborate with business owners to integrate TPRM requirements into vendor management processes.
Support the development and delivery of training materials and workshops to enhance awareness and adoption of TPRM policies and processes.

Governance & Compliance

Assist in preparing materials for governance forums, including reporting, key metrics, and summaries.
Ensure compliance with internal policies, regulatory requirements, and industry standards.
Stay updated on changes in regulatory requirements and industry best practices to ensure the TPRM program remains current and effective.

Requirements
  • Bachelor’s degree in Business, Finance, Risk Management, or a related field.
  • 5–7 years of experience in third-party risk management, sourcing, or compliance, preferably in a regulated industry.
  • Hands-on experience with TPRM tools such as ProcessUnity, Archer, RiskConnect, or similar platforms.
  • Strong organizational and communication skills, with a focus on stakeholder engagement and user support.
  • Proven ability to manage operational processes and track issue resolution.
  • Familiarity with third-party risk management policies, tools, and processes.
  • Experience in collaborating with business owners and vendors to address and resolve inquiries.
  • Experience in biopharma, biotech, or a related field is preferred but not mandatory.
  • Proficiency in Microsoft Office and other relevant tools.

Success Measures

  • Effective management of TPRM operations, including risk tools and issue tracking.
  • High levels of stakeholder satisfaction with TPRM support and user engagement.
  • Timely resolution of findings and issues from risk assessments.
  • Improved efficiency and effectiveness of TPRM processes through process optimization and automation.

About the Company

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and has made significant advancements in multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, and acute pain — and continues to progress clinical and research programs in these diseases. We also have a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where we have deep insight into causal human biology, including acute and neuropathic pain, APOL1-mediated kidney disease, IgA nephropathy, autosomal dominant polycystic kidney disease, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency.

Our global headquarters is in Boston, and we have research and development (R&D) sites and commercial offices worldwide.

Vertex is consistently recognized as one of the industry’s top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. We have also earned a spot on TIME Most Influential Companies, TIME Best Inventions, and Fast Company Most Innovative Companies lists. Our research and medicines have received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the Prix Galien, the Scrip Award and the Breakthrough Prize awards.

bottom of page